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Nutritional science (also nutrition science, sometimes short nutrition, dated trophology) is the science that studies the physiological process of nutrition (primarily human nutrition), interpreting the nutrients and other substances in food in relation to maintenance, growth, reproduction, health and disease of an organism. Before nutritional science emerged as an independent study disciplines, mainly chemists worked in this area. The chemical composition of food was examined. Macronutrients, especially protein, fat and carbohydrates, have been the focus components of the study of (human) nutrition since the 19th century. Until the discovery of vitamins and vital substances, the quality of nutrition was measured exclusively by the intake of nutritional energy. The early years of the 20th century were summarized by Kenneth John Carpenter in his Short History of Nutritional Science as "the vitamin era". The first vitamin was isolated and chemically defined in 1926 (thiamine). The isolation of vitamin C followed in 1932 and its effects on health, the protection against scurvy, was scientifically documented for the first time. At the instigation of the British physiologist John Yudkin at the University of London, the degrees Bachelor of Science and Master of Science in nutritional science were established in the 1950s. Nutritional science as a separate discipline was institutionalized in Germany in November 1956 when Hans-Diedrich Cremer was appointed to the chair for human nutrition in Giessen. The Institute for Nutritional Science was initially located at the Academy for Medical Research and Further Education, which was transferred to the Faculty of Human Medicine when the Justus Liebig University was reopened. Over time, seven other universities with similar institutions followed in Germany. From the 1950s to 1970s, a focus of nutritional science was on dietary fat and sugar. From the 1970s to the 1990s, attention was put on diet-related chronic diseases and supplementation.