Papyrus 46 (P. Chester Beatty II), designated by siglum (in the Gregory-Aland numbering), is an early Greek New Testament manuscript written on papyrus, and is one of the manuscripts comprising the Chester Beatty Papyri. Manuscripts among the Chester Beatty Papyri have had several provenances associated with them, the most likely being the Faiyum. It has been paleographically dated between 175 and 225, or early 3rd century CE. It contains verses from the Pauline Epistles of Romans, 1 Corinthians, 2 Corinthians, Galatians, Ephesians, Colossians, Philippians, 1 Thessalonians, and Hebrews. Some leaves are part of the Chester Beatty Biblical Papyri, and others are in the University of Michigan Papyrus Collection.
In November 2020, the Center for the Study of New Testament Manuscripts (CSNTM) in conjunction with Hendrickson Publishers released a new 1:1 high-resolution imaged facsimile edition of on black and white backgrounds, along with and .
The codex is made from papyrus in single quire, with the folio size approximately . The text is written in single column, with the text-block averaging , between 26 and 32 lines of text per page, although both the width of the rows and the number of rows per page increase progressively. Lines containing text at the bottom of each page are damaged (lacunose), with between 1–2 lines non-extant in the first quarter of the codex, 2–3 lines non-extant in the central half, and up to seven lines non-extant in the final quarter. Though unusual for ancient manuscripts, has each page numbered.
Throughout Romans, Hebrews, and the latter chapters of 1 Corinthians, small and thick strokes or dots are found, usually agreed to be from the hand of a reader rather than the initial copyist, since the ink is always much paler than that of the text itself. They appear to mark sense divisions (similar to verse numbering found in Bibles), and are also found in portions of , possibly evidence of reading in the community which held both codices.