The Geneva Bible is one of the most historically significant translations of the Bible into English, preceding the King James Version by 51 years. It was the primary Bible of 16th century English Protestantism and was used by William Shakespeare, Oliver Cromwell, Scotsman John Knox, John Donne, and others. It was one of the Bibles taken to America on the Mayflower (Pilgrim Hall Museum has collected several Bibles of Mayflower passengers). The Geneva Bible was used by many English Dissenters, and it was still respected by Oliver Cromwell's soldiers at the time of the English Civil War, in the booklet The Souldiers Pocket Bible.
This version of the Bible is significant because, for the first time, a mechanically printed, mass-produced Bible was made available directly to the general public which came with a variety of scriptural study guides and aids (collectively called an apparatus), which included verse citations that allow the reader to cross-reference one verse with numerous relevant verses in the rest of the Bible, introductions to each book of the Bible that acted to summarize all of the material that each book would cover, maps, tables, woodcut illustrations and indices.
Because the language of the Geneva Bible was more forceful and vigorous, most readers strongly preferred this version to the Great Bible. In the words of Cleland Boyd McAfee, "it drove the Great Bible off the field by sheer power of excellence".
The Geneva Bible followed the Great Bible of 1539, the first authorized Bible in English, which was the authorized Bible of the Church of England.
During the reign of Queen Mary I of England (1553–1558), because Mary I was Catholic, a number of Protestant scholars fled from England to Geneva, Switzerland, which was then ruled as a republic in which John Calvin and, later, Theodore Beza, provided the primary spiritual and theological leadership. Among these scholars was William Whittingham, who supervised the translation now known as the Geneva Bible, in collaboration with Myles Coverdale, Christopher Goodman, Anthony Gilby, Thomas Sampson, and William Cole; several of this group later became prominent figures in the Vestments controversy.