São Paulo (sɐ̃w ˈpawlu) is one of the 26 states of the Federative Republic of Brazil and is named after Saint Paul of Tarsus. A major industrial complex, the state has 21.9% of the Brazilian population and is responsible for 33.9% of Brazil's GDP. São Paulo also has the second-highest Human Development Index (HDI) and GDP per capita, the fourth-lowest infant mortality rate, the third-highest life expectancy, and the third-lowest rate of illiteracy among the federative units of Brazil. São Paulo alone is wealthier than Argentina, Uruguay, Paraguay, and Bolivia combined. São Paulo is also the world's twenty-eighth-most populous sub-national entity and the most populous sub-national entity in the Americas. With more than 46 million inhabitants in 2019, São Paulo is the most populous Brazilian state, the most populous national subdivision in the Americas, and the third most populous political unit of South America, surpassed only by the rest of the Brazilian Federation and Colombia. The local population is one of the most diverse in the country and descended mostly from Italians, who began immigrating to the country in the late 19th century; the Portuguese, who colonized Brazil and installed the first European settlements in the region; indigenous peoples, many distinct ethnic groups; Africans, who were brought from Africa as slaves in the colonial era and migrants from other regions of the country. In addition, Arabs, Armenians, Germans, Spanish, Japanese, Chinese, and Greeks also are present in the ethnic composition of the local population. The area that today corresponds to the state territory was already inhabited by indigenous peoples from approximately 12,000 BC. In the early 16th century, the coast of the region was visited by Portuguese and Spanish explorers and navigators. In 1532 Martim Afonso de Sousa would establish the first Portuguese permanent settlement in the Americas—the village of São Vicente, in the Baixada Santista.