The multiregional hypothesis, multiregional evolution (MRE), or polycentric hypothesis, is a scientific model that provides an alternative explanation to the more widely accepted "Out of Africa" model of monogenesis for the pattern of human evolution.
Multiregional evolution holds that the human species first arose around two million years ago and subsequent human evolution has been within a single, continuous human species. This species encompasses all archaic human forms such as H. erectus and Neanderthals as well as modern forms, and evolved worldwide to the diverse populations of anatomically modern humans (Homo sapiens).
The hypothesis contends that the mechanism of clinal variation through a model of "Centre and Edge" allowed for the necessary balance between genetic drift, gene flow and selection throughout the Pleistocene, as well as overall evolution as a global species, but while retaining regional differences in certain morphological features. Proponents of multiregionalism point to fossil and genomic data and continuity of archaeological cultures as support for their hypothesis.
The multiregional hypothesis was first proposed in 1984, and then revised in 2003. In its revised form, it is similar to the Assimilation Model, which holds that modern humans originated in Africa and today share a predominant recent African origin, but have also absorbed small, geographically variable, degrees of admixture from other regional (archaic) hominin species.
The Multiregional hypothesis was proposed in 1984 by Milford H. Wolpoff, Alan Thorne and Xinzhi Wu. Wolpoff credits Franz Weidenreich's "Polycentric" hypothesis of human origins as a major influence, but cautions that this should not be confused with polygenism, or Carleton Coon's model that minimized gene flow. According to Wolpoff, multiregionalism was misinterpreted by William W. Howells, who confused Weidenreich's hypothesis with a polygenic "candelabra model" in his publications spanning five decades:
How did Multiregional evolution get stigmatized as polygeny? We believe it comes from the confusion of Weidenreich's ideas, and ultimately of our own, with Coon's.
This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.
In vitro cytotoxicity testing is often the first step to establish the utility of a compound as a potential drug. The course will teach students how to evaluate the cytotoxicity of compounds on cancer
In paleoanthropology, the recent African origin of modern humans is the dominant model of the geographic origin and early migration of anatomically modern humans (Homo sapiens). It follows the early expansions of hominins out of Africa, accomplished by Homo erectus and then Homo neanderthalensis. The model proposes a "single origin" of Homo sapiens in the taxonomic sense, precluding parallel evolution in other regions of traits considered anatomically modern, but not precluding multiple admixture between H.
Neanderthals (niˈændə(r)ˌtɑːl,neɪ-,-ˌθɑːl; Homo neanderthalensis or H. sapiens neanderthalensis), also written as Neandertals, are an extinct species or subspecies of archaic humans who lived in Eurasia until about 40,000 years ago. The reasons for Neanderthal extinction are disputed. Theories for their extinction include demographic factors such as small population size and inbreeding, competitive replacement, interbreeding and assimilation with modern humans, climate change, disease, or a combination of these factors.
The Denisovans or Denisova hominins (prondɪˈniːsəvə ) are an extinct species or subspecies of archaic human that ranged across Asia during the Lower and Middle Paleolithic. Denisovans are known from few physical remains; consequently, most of what is known about them comes from DNA evidence. No formal species name has been established pending more complete fossil material. The first identification of a Denisovan individual occurred in 2010, based on mitochondrial DNA (mtDNA) extracted from a juvenile female finger bone excavated from the Siberian Denisova Cave in the Altai Mountains in 2008.
The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...
London2023
, ,
Background Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins ...
Providing a naturalistic tactile sensory feedback is currently one of the key challenges in neuroprosthetics. Modeling has played a fundamental role in the development of "biomimetic" stimulation protocols, determining optimal activation patterns to be eli ...