Pflügers Archiv: European Journal of Physiology is a peer-reviewed scientific journal in the field of physiology. A continuation of a journal founded in 1868 by the German physiologist, Eduard Friedrich Wilhelm Pflüger, Pflügers Archiv (ˈpflyːɡɐs aʁˈçiːf) is the oldest physiological journal. Pflügers Archiv is currently published by Springer, with 11 issues per year.
The journal publishes molecular and cellular studies across the physiological sciences; topics include the physiology of the heart, muscle and sensory systems, transport physiology, neuroscience, signalling, ion channels and receptors. It aims to publish "innovative work that focuses on mechanistic insight into basic physiological functions".
Pflügers Archiv is the oldest physiological journal. It was founded in 1868 by the German physiologist, Eduard Friedrich Wilhelm Pflüger, under the title Archiv für die gesamte Physiologie des Menschen und der Tiere. It was published in German. The first issue of the journal contains 26 articles, with contributors including Hermann Rudolph Aubert, Julius Bernstein, Johann Nepomuk Czermak, Franciscus Donders, Sigmund Exner, Siegmund Mayer, Peter Ludvig Panum, William Thierry Preyer, Salomon Stricker, Hermann von Helmholtz, Friedrich Wilhelm Zahn and Nathan Zuntz. It includes the earliest accurate description of the action potential, by Julius Bernstein, using an apparatus called a "differential rheotome".
The journal was mainly published annually until 1874; there were two or three volumes annually in 1874–1890. From 1891, the volume was split into issues, with five or six issues per volume, and initially three volumes published a year; volumes often did not commence in January. The frequency of volumes increased, with five volumes in 1909.
In 1910, after Pflüger's death, the journal was retitled Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere (). It was published by Springer in German, with some English translations of summaries. Several other German physiology journals merged into the publication: in 1919, Archiv für Anatomie und Physiologie.