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Umair in the city, Nusaybah and Umm Munee Asma bint ʿAmr bin 'Adi were the only two women to personally pledge directly to the Islamic prophet Muhammad. The latter's husband, Ghazyah bin ʿAmr, informed Muhammad that the women also wanted to give them their bayah in person, and he agreed. She returned to Medina and began teaching Islam to the women of the city. This bayah or pledge was the de facto handing over power to Muhammad over the city, by its key figures.
Her most prominent role came in the Battle of Uhud, where she defended the prophet. She also participated in the battle of Hunain, Yamamah and the Treaty of Hudaybia.
Her two sons, both later martyrs in battle, were from her first marriage to Zaid bin ʿAsim Mazni. She later married bin ʿAmr, and had another son Tameem and a daughter Khawlah.