Zhi Ming Xu

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Related publications (16)

Improving polygenic prediction with genetically inferred ancestry

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Zhi Ming Xu

Genome-wide association studies (GWASs) have demonstrated that most common diseases have a strong genetic component from many genetic variants each with a small effect size. GWAS summary statistics have allowed the construction of polygenic scores (PGSs) e ...

ELSEVIER2022

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

SPRINGERNATURE2020

Polygenic modelling of treatment effect heterogeneity

Zhi Ming Xu

Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking) genetic variant that can be used ...

2020

Genome-to-genome analysis identifies an Asian-specific variant in the gene encoding NTCP that leads to specific HBV escape mutations during chronic infection

Jacques Fellay, Zhi Ming Xu, Sina Rüeger

SPRINGERNATURE2020

A privacy-preserving solution for compressed storage and selective retrieval of genomic data

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Adam Molyneaux, Zhicong Huang, Huang Lin, Zhi Ming Xu

In clinical genomics, the continuous evolution of bioinformatic algorithms and sequencing platforms makes it beneficial to store patients' complete aligned genomic data in addition to variant calls relative to a reference sequence. Due to the large size of ...

Cold Spring Harbor Laboratory2016

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Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

SPRINGERNATURE2020

Genome-to-genome analysis identifies an Asian-specific variant in the gene encoding NTCP that leads to specific HBV escape mutations during chronic infection

Jacques Fellay, Zhi Ming Xu, Sina Rüeger

SPRINGERNATURE2020