Environmental toxicologyEnvironmental toxicology is a multidisciplinary field of science concerned with the study of the harmful effects of various chemical, biological and physical agents on living organisms. Ecotoxicology is a subdiscipline of environmental toxicology concerned with studying the harmful effects of toxicants at the population and ecosystem levels. Rachel Carson is considered the mother of environmental toxicology, as she made it a distinct field within toxicology in 1962 with the publication of her book Silent Spring, which covered the effects of uncontrolled pesticide use.
Primary cell culturePrimary cell culture is the ex vivo culture of cells freshly obtained from a multicellular organism, as opposed to the culture of immortalized cell lines. In general, primary cell cultures are considered more representative of in vivo tissues than cell lines, and this is recognized legally in some countries such as the UK (Human Tissue Act 2004). However, primary cells require adequate substrate and nutrient conditions to thrive and after a certain number of divisions they acquire a senescent phenotype, leading to irreversible cell cycle arrest.
Law of multiple proportionsIn chemistry, the law of multiple proportions states that if two elements form more than one compound, then the ratios of the masses of the second element which combine with a fixed mass of the first element will always be ratios of small whole numbers. This law is also known as Dalton's Law, named after John Dalton, the chemist who first expressed it. For example, Dalton knew that the element carbon forms two oxides by combining with oxygen in different proportions.
I386The Intel 386, originally released as 80386 and later renamed i386, is a 32-bit microprocessor introduced in 1985. The first versions had 275,000 transistors and were the CPU of many workstations and high-end personal computers of the time. As the original implementation of the 32-bit extension of the 80286 architecture, the i386 instruction set, programming model, and binary encodings are still the common denominator for all 32-bit x86 processors, which is termed the i386 architecture, x86, or IA-32, depending on context.
