Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

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In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...

EPFL2022

Epigenetic plasticity as a signature for memory allocation

Giulia Santoni

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

EPFL2022

Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces

Silvestro Micera

Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, ...

MDPI2022

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Katarina Pinjusic

Activin-A, a transforming growth factor ê µ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...

EPFL2022

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Stéphanie Lacour

Fibrotic scarring secondary to the foreign body reaction (FBR) generates a physical barrier obstructing the functional interaction of implantable medical devices with the host tissue. The mechanistic basis of the FBR is poorly understood, restricting the c ...

National Academy of Sciences2022

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

Johan Auwerx, Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Marie-Isabelle Guillot de Suduiraut, João Pedro de Matos Rodrigues, Wei Huang, Ioannis Zalachoras, Sriparna Ghosal

Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-b ...

2022

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Sebastian Maerkl, Ragunathan Bava Ganesh

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

FRONTIERS MEDIA SA2022

Mechanical principles of engineering fibrous tissues with programmable shape

Erik Mailand

The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...

EPFL2021

New Insights into the Interface of Electrochemical Flow Cells for Carbon Dioxide Reduction to Ethylene

Michael Graetzel, Shaik Mohammed Zakeeruddin, Jing Gao, Dan Ren

The implementation of an electrochemical flow cell has enabled improved efficiency for CO2 reduction. However, in situ spectroscopic insights into the interface are still lacking. Here, we investigate a series of copper layers with different thicknesses on ...

AMER CHEMICAL SOC2021

Soft materials and technologies for neural interfaces

Michael Shur

Implantable neural interfaces are an emerging concept which is revolutionizing various domains of medicine and rehabilitation. However, the long-term efficiency and reliability of these devices is often limited, mainly attributed to the fundamental differe ...

EPFL2021

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eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

2022