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Versatile palladium-catalyzed double carbonylation of aryl bromides

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Paul Joseph Dyson, Gabor Laurenczy, Cornel Fink, Xinbang Wu
2017
journal articles

Abstract

A versatile palladium-catalyzed double carbonylation of aryl bromides has been developed. Using Pd(OAc)2/BuPAd2 as the catalyst system and DBU as the base, under relatively low CO pressure, various a-ketoamides were produced in good yields. In order to get insight into the reaction pathway, real time NMR studies were performed as well and a correlated reaction mechanism is been given.

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https://infoscience.epfl.ch/entities/publication/8b3e623c-ccd9-4f3e-a27c-d301165228c4

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