Imagining with and in Space: Structural support as a cognitive device in architectural education

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Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone

Christian Heinis, Jonas Alfred Karl Wilbs, Simon Jan Middendorp

Cyclic peptides binding to targets of interest can be generated efficiently with powerful in vitro display techniques, such as phage display or mRNA display. The cyclic peptide libraries screened with these methods are generated by altering in a combinator ...

2016

Stress and cognition

Maria del Carmen Sandi Perez

Stress can affect cognition in many ways, with the outcome (i.e., facilitating or impairing) depending on a combination of factors related to both stress and the cognitive function under study. Among the factors identified as particularly relevant to defin ...

Wiley-Blackwell2013

Improving Remaining-Fatigue-Life Evaluation Using Data Interpretation

Ian Smith, Yves Sylvain Gilles Reuland, Romain Pasquier

This paper presents a methodology that improves fatigue-performance evaluations using model-based data interpretation. The accuracy of stress-range values is essential for quantifying fatigue damage. These values are usually predicted using physics-based m ...

2013

Mixed-Mode Static and Fatigue Failure Criteria for Adhesively-Bonded FRP Joints

Moslem Shahverdi

Fiber-reinforced polymer (FRP) composites are increasingly used in many load-bearing structures. Joints are the most critical structural elements as they often become the weak links in engineering structures. Bonding and bolting are two of the main joini ...

EPFL2013

The 3A Interaction Model and Relation-Based Recommender System : Adopting Social Media Paradigms in Designing Personal Learning Environments

Sandy Ingram

We live in a rapidly changing digital world marked by technological advances, and fraught with online information constantly growing thanks to the Internet revolution and the online social applications in particular. Formal learning acquired in traditional ...

EPFL2010

Stress-induced cognitive and psychopathological alterations : functional involvement of the neural cell adhesion molecule (NCAM)

Maria del Carmen Sandi Perez, Reto Bisaz

Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...

EPFL2009

Spatial navigation in geometric mazes : a computational model of rodent behavior

Navigation is defined as the capability of planning and performing a path from the current position towards a desired location. Different types, or strategies, of navigation are used by animals depending on the task they are trying to solve. Visible goals ...

EPFL2007

Spatial learning and navigation in the rat : a biomimetic model

Ricardo Andres Chavarriaga Lozano

Animals behave in different ways depending on the specific task they are required to solve. In certain cases, if a cue marks the goal location, they can rely on simple stimulusresponse associations. In contrast, other tasks require the animal to be endowed ...

EPFL2005

Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval

Pierre Magistretti, Luc Pellerin

Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding of hippocampal function. Using the (14C)-2-deoxyglucose autoradiographic method, we have chara ...

2005