Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents

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Reactivity and biological activity of N,N,S-Schiff-base rhodium pentamethylcyclopentadienyl complexes

Paul Joseph Dyson, Lucinda Kate Batchelor

Neutral piano-stool complexes of the general formula [(eta(5)-C5Me5)Rh(L-OR)] (R = Me, 1; R = Et, 2; R = Pe(i), 3) have been prepared in alcohols (methanol, 1; ethanol, 2; isopropanol, 3) from the Schiff-base 5-methyl-4-{(pyridin-2-ylmethylene)amino}-4H-1, ...

ELSEVIER SCIENCE SA2020

Conjugating Biotin to Ruthenium(II) Arene Units via Phosphine Ligand Functionalization

Paul Joseph Dyson, Lucinda Kate Batchelor, Andrea Monti

Two-step functionalization of 4-diphenylphosphino benzoic acid with biotin afforded 2-(biotinyloxy)ethyl 4-(diphenylphosphanyl)benzoate (LP), that was subsequently used to synthesize the Ru(II) arene complexes [RuCl2(eta(6)-p-cymene)(LP)] (1), [Ru(C2O4)(et ...

2020

Synthesis, characterization and cytotoxicity of arene-ruthenium(II) complexes with acylpyrazolones functionalized with aromatic groups in the acyl moiety

Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel

A series of neutral ruthenium(II)-arene complexes, [(arene) Ru(Q(R))Cl] (arene = p-cymene or hexamethylbenzene), containing 4-acyl-5-pyrazolonate (Q(R)) ligands with aromatic substituents in the acyl moiety (a phenyl in Q(Ph) and a 1-naphthyl in Q(naph)) a ...

2018

Composite Materials Based on (Cymene)Ru(II) Curcumin Additives Loaded on Porous Carbon Adsorbents from Agricultural Residues Display Efficient Antibacterial Activity

Paul Joseph Dyson

Alternative composite materials with antibacterial activity have been developed by combining the porosity of carbon materials and the antibacterial activity of half sandwich (cymene)Ru-curcumin complexes. Different types of activated carbon were used, from ...

2018

Selecting the best AOP for isoxazolyl penicillins degradation as a function of water characteristics: Effects of pH, chemical nature of additives and pollutant concentration

César Pulgarin, Paola Villegas Guzman

To provide new insights toward the selection of the most suitable AOP for isoxazolyl penicillins elimination, the degradation of dicloxacillin, a isoxazolyl penicillin model, was studied using different advanced oxidation processes (AOPs): ultrasound (US), ...

Elsevier2017

Synthesis and In Vitro (Anticancer) Evaluation of eta(6)-Arene Ruthenium Complexes Bearing Stannyl Ligands

Paul Joseph Dyson, Tina Riedel

Treatment of the known half-sandwich complexes of the type [(eta(6)-C6H6)RuCl2(P(OR)(3))] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1-C3): [(eta(6)-C6H6)RuCl(SnCl3)(P(OMe)(3))] (C1), [(eta(6)-C6H6)RuCl(SnCl3)(P(OPh)(3) ...

2017

p,t-[Ru(CO)(PR3)(tren)](2+) [R=Ph or p-tol; tren=tris(2-aminoethyl)amine], Ru(II) complexes bearing a simple tripodal tetradentate amine: synthesis, characterization, and antimicrobial activity

Paul Joseph Dyson, Rosario Scopelliti, Francisco Dinis Fagundes

Complexes with general formula p,t-[Ru(CO)(PR3)(tren)]X-2 [R=Ph (1) or p-tol (2); tren=tris(2-aminoethyl)amine; X=Cl- or PF6-] were prepared from [RuCl2(CO)(dmf)(PR3)] by direct reaction with tren. The complexes were fully characterized by NMR (H-1, P-31{H ...

Taylor & Francis2016

Synthesis, Structure, and Anticancer Activity of Arene-Ruthenium(II) Complexes with Acylpyrazolones Bearing Aliphatic Groups in the Acyl Moiety

Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel

A series of neutral ruthenium(II) arene complexes [(arene)Ru(Q(R))Cl] (arene = p-cymene (cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate Q(R) ligands with different electronic and steric substituents (R = 4-cyclohexyl, 4-stearoyl, or 4-ad ...

American Chemical Society2016

Total Synthesis of (±)-Strictamine

Qian Wang, Jieping Zhu, Weiwu Ren

The total synthesis of strictamine has been achieved in nine steps from a known enol triflate. Characteristic features of our approach included: a) creation of a C7 all-carbon quaternary stereocenter at an early synthetic stage; b) use of an N,N-dimethyl t ...

Wiley-Blackwell2016

Anti-microbial dendrimers against multidrug-resistant P. aeruginosa enhance the angiogenic effect of biological burn-wound bandages

Dominique Pioletti, Philippe Abdel Sayed, Lee Ann Laurent-Applegate, Jean-Louis Reymond, Paris Jafari

Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with signi cant morbidity ...

Nature Research2016

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