Alginate-Poly(ethylene glycol) Hybrid Microspheres with Adjustable Physical Properties

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Hybrid granular hydrogels: combining composites and microgels for extended ranges of material properties

Dominique Pioletti, Pierre-Etienne Bourban, Peyman Karami, Céline Samira Wyss

Developing hydrogels with optimal properties for specific applications is challenging as most of these properties, such as toughness, stiffness, swelling or deformability, are interrelated. The improvement of one property usually comes at the cost of anoth ...

2020

PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids

Nicolas Antoine Vincent Broguiere, Martin Ehrbar, Queralt Vallmajó Martín

Bone marrow (BM) organoids provide powerful tools to study the vital interplay between the BM microenvironment and resident cells. Current biomaterials, however, are limited in terms of versatility for independently studying the biochemical and biophysical ...

WILEY-V C H VERLAG GMBH2020

Stainless steel-like FeCrNi nanostructures via electrodeposition into AAO templates using a mixed-solvent Cr(III)-based electrolyte

Enrico Bertero

Electrodeposition of stainless steel-like materials such as FeCrNi alloy into micro- and nanotemplates provides a sustainable framework for creating biomedical-oriented micro- and nanocomponents with outstanding characteristics. While Cr(III)-based electro ...

2020

Modular soft robotic microdevices for dexterous biomanipulation

Francesco Stellacci, Mahmut Selman Sakar, Ece Özelçi, Ahmet Bekdemir, Murat Kaynak, Berna Ayse Özkale Edelmann, Raquel Filipa Penacho Parreira, Lucio Feo Pancaldi-Giubbini

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransduce ...

2019

A General and Facile Approach for the Electrochemical Reduction of Carbon Dioxide Inspired by Deep Eutectic Solvents

Paul Joseph Dyson, Dmitry Vasilyev

Deep eutectic solvents (DESs) were applied to the electrochemical CO2 reduction reaction (CO2RR). Choline-based DESs represent a non-toxic and inexpensive alternative to room-temperature ionic liquids (RTILs) as additives to the system or as electrolyte. F ...

2019

Polymeric Micelles Loading Proteins through Concurrent Ion Complexation and pH-Cleavable Covalent Bonding for In Vivo Delivery

Francesco Stellacci, Suiyang Liao

Protein drugs have great potential as targeted therapies, yet their application suffers from several drawbacks, such as instability, short half-life, and adverse immune responses. Thus, protein delivery approaches based on stimuli-responsive nanocarriers c ...

WILEY-V C H VERLAG GMBH2019

Fluorinated surfactants in droplet-based microfluidics: Influence of their composition on the properties of emulsion drops

Gianluca Nicolas Etienne

Miniaturization has been a driving force in many areas of science and technology, most notably in the electronics industry. Droplet-based microfluidics, a methode to produce emulsion drops in a controlled way and at high-throughputs, enables the miniaturiz ...

EPFL2019

Cross-Reactive Alginate Derivatives for the Production of Dual Ionic−Covalent Hydrogel Microspheres Presenting Tunable Properties for Cell Microencapsulation

Sandrine Gerber, Aurélien Bornet, François Rémi Pierre Noverraz, Luca Szabó

The production of hydrogel micropsheres (MS) presenting physical, mechanical, and biological properties which can be modulated by their chemical composition is required to enlarge the panel of biomaterials for cell transplantation therapies. Functionalizat ...

2019

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Peyman Karami, Pierre-Etienne Bourban, Christophe Moser, Andreas Schmocker, Azadeh Khoushabi, Céline Samira Wyss, Martin Broome

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

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