Publications related to Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Rodents depend on olfaction and touch to meet many of their fundamental needs. However, the impact of simultaneous olfactory and tactile inputs on sensory representations in the cortex remains elusive. To study these interactions, we recorded large populat ...

Nature Portfolio2022

Shedding light on excessive crying in babies

Dimitri Nestor Alice Van De Ville, François Lazeyras, Lorena Gonçalves de Alcântara e Freitas Krikler

Background Excessive and inconsolable crying behavior in otherwise healthy infants (a condition called infant colic (IC)) is very distressing to parents, may lead to maternal depression, and in extreme cases, may result in shaken baby syndrome. Despite the ...

NATURE PUBLISHING GROUP2021

Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening

Sandro Carrara, Tugba Kilic, Hatice Altug, Maria Soler Aznar

The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening met ...

2018

The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

Bruno Lemaitre

Behavioral resistance protects insects from microbial infection. However, signals inducing insect hygiene behavior are still relatively unexplored. Our previous study demonstrated that olfactory signals from microbes enhance insect hygiene behavior, and gu ...

Public Library of Science2017

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Matteo Dal Peraro, Benoîte Bargeton

Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Mori ...

Elsevier2017

Subject-Independent Odor Pleasantness Classification Using Brain and Peripheral Signals

Touradj Ebrahimi, Jean-Marc Vesin, Eleni Kroupi

Enhanced sensation of reality from multimedia contents can be achieved by creating realistic multimedia environments, using visual, auditory, and olfactory information. Although the affective information from video and audio has been extensively studied, t ...

Ieee-Inst Electrical Electronics Engineers Inc2016

Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae

Philippe Renaud

Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversio ...

Nature Publishing Group2016

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Vogel, Horst Pick, Shuguang Yuan, Luc Veya, Olivia Baud

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

Functional Characterization of the Mouse Olfactory Receptor mOR256-17 in Live Cells

Thamani Dahoun

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system to recognize and discriminate a nearly unlimited number of structurally diverse odorant molecules. The molecul ...

EPFL2013

Probing Odorant-Mediated Receptor Activation

Olivia Baud

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the mammalian olfactory system to detect and discriminate a large variety of odors with a limited set of receptors. How a particular OR binds and distingu ...

EPFL2012