Publication

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Publications associées (192)

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Henry Markram, Gilad Silberberg, Tania Rinaldi

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2008

Structure and dynamics of the neocortical microcircuit connectivity

Jean-Vincent Le Bé

The neocortex is the most computationally advanced portion of the brain. It is currently assumed to be composed of a large number of "cortical columns" – intricate arrangements of cortical neurons approximately 300-500 µm in diameter and 2-5 mm in height i ...

EPFL2007

Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex

Carl Petersen, Sylvain Crochet, Thomas Berger, Sandrine Lefort

Cortical dynamics can be imaged at high spatiotemporal resolution with voltage-sensitive dyes (VSDs) and calcium-sensitive dyes (CaSDs). We combined these two imaging techniques using epifluorescence optics together with whole cell recordings to measure th ...

2007

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells

Henry Markram, Gilad Silberberg

Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcirc ...

2007

Predicting neuronal activity with simple models of the threshold type: Adaptive Exponential Integrate-and-Fire model with two compartments

Wulfram Gerstner, Renaud Jolivet, Claudia Clopath

An adaptive Exponential Integrate-and-Fire (aEIF) model was used to predict the activity of layer-V-pyramidal neurons of rat neocortex under random current injection. A new protocol has been developed to extract the parameters of the aEIF model using an op ...

Elsevier2007

Neuron models of the generic bifurcation type

Minimal nonlinear dynamic neuron models of the generic bifurcation type may provide the middle way between the detailed models favored by experimentalists and the simplified threshold and rate model of computational neuroscientists. This thesis investigate ...

EPFL2006

Spontaneous and evoked synaptic rewiring in the neonatal neocortex

Henry Markram, Jean-Vincent Le Bé

The local microcircuitry of the neocortex is structurally a tabula rasa, with the axon of each pyramidal neuron having numerous submicrometer appositions with the dendrites of all neighboring pyramidal neurons, but is functionally highly selective, with sy ...

2006

Statistics of subthreshold neuronal voltage fluctuations due to conductance-based synaptic shot noise

Wulfram Gerstner

Neurons in the central nervous system, and in the cortex in particular, are subject to a barrage of pulses from their presynaptic populations. These synaptic pulses are mediated by conductance changes and therefore lead to increases or decreases of the neu ...

2006

Generalized Bienenstock-Cooper-Munro rule for spiking neurons that maximizes information transmission

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Taro Toyoizumi

Maximization of information transmission by a spiking-neuron model predicts changes of synaptic connections that depend on timing of pre- and postsynaptic spikes and on the postsynaptic membrane potential. Under the assumption of Poisson firing statistics, ...

2005

The neocortical microcircuit as a tabula rasa

Henry Markram, Gilad Silberberg

The neocortex has a high capacity for plasticity. To understand the full scope of this capacity, it is essential to know how neurons choose particular partners to form synaptic connections. By using multineuron whole-cell recordings and confocal microscopy ...

2005

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