Publication

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

Publications associées (300)

Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy

Françoise Gisou van der Goot Grunberg, Nicolas Dupont

Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected ...

2009

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

Etienne Meylan

NF-kappaB transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite extensive biochemical characteriz ...

2009

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK

Bruno Lemaitre

BACKGROUND: The JNK pathway is a mitogen-activated protein (MAP) kinase pathway involved in the regulation of numerous physiological processes during development and in response to environmental stress. JNK activity is controlled by two MAPK kinases (MAPKK ...

Public Library of Science2009

Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways

Bruno Lemaitre

Invertebrates lack an adaptive immune system and rely on innate immunity to resist pathogens. The response of Drosophila melanogaster to bacterial and fungal infections involves two signaling pathways, Toll and Imd, both of which activate members of the nu ...

Humana Press2008

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

Bruno Lemaitre

Metazoans tolerate commensal-gut microbiota by suppressing immune activation while maintaining the ability to launch rapid and balanced immune reactions to pathogenic bacteria. Little is known about the mechanisms underlying the establishment of this thres ...

2008

Toll-like receptors--taking an evolutionary approach

Bruno Lemaitre

The Toll receptor was initially identified in Drosophila melanogaster for its role in embryonic development. Subsequently, D. melanogaster Toll and mammalian Toll-like receptors (TLRs) have been recognized as key regulators of immune responses. After ten y ...

2008

Intracellular pattern-recognition receptors

Etienne Meylan

The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in ...

Elsevier2008

MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells

The retinal pigment epithelium (RPE) is constantly exposed to external injuries which lead to degeneration, dysfunction or loss of RPE cells. The balance between RPE cells death and proliferation may be responsible for several diseases of the underlying re ...

2008

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo

Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) constitute the single largest class of proteinaceous bacterial virulence factors and are made by many of the most important bacterial pathogens. Host responses to these toxins are complex and poorly understood. We find that the e ...

2008

Identification of the Design Principles of Signaling Pathways for Metabolic Engineering

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat, Andrijana Radivojevic

The mitogen-activated protein kinase (MAPK) cascades are ubiquitous in eukaryotic signal transduction, and these pathways are conserved in cells from yeast to mammals. Metabolic engineering of mammalian cells requires the redesign of the steady-sate and th ...

2008

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search