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Prediction of bone density around orthopedic implants delivering bisphosphonate

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Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari, Tatiana Kochetkova

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

Johan Auwerx, Dongryeol Ryu, Olivier Staub, Lilia Noriega Lopez

SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...

2021

Atomistic simulation and electron microscopy to characterize grain boundaries in doped beta-tricalcium phosphate ceramics

Gabrielle Anne Laguisma Sblendorio

The limitations and potential complications correlated with autogenous bone grafts have raised interest in the development of synthetic bone graft substitutes. ß-tricalcium phosphate (ß-TCP) is one of the most promising materials for synthetic bone graft s ...

EPFL2021

A Crevice Corrosion Model for Biomedical Trunnion Geometries and Surfaces Feature

Stefano Mischler, Anna Neus Igual Muñoz, Angela Bermudez Castañeda

Modular hip joint implants were introduced in arthroplasty medical procedures because they facilitate the tailoring of patients’ anatomy, the use of different materials in one single configuration, as well as medical revision. However, in certain cases, su ...

2021

Multi-scale modeling of aggregate interlock phenomena in concrete

Mohit Pundir

In concrete structures, opened cracks contribute significantly to the transfer of shear and normal stresses through the contact forces occurring between fractured surfaces. Such contact forces are due to protruding asperities, engaged by interlocking and f ...

EPFL2021

A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

Daniel Keller, Andrii Stepaniuk

Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a ...

HUMANA PRESS INC2022

Advantages of patient-specific cutting guides with disposable instrumentation in total knee arthroplasty: a case control study

Brigitte Jolles-Haeberli

BackgroundTotal knee arthroplasty (TKA) is most frequently planned using conventional two-dimensional weight-bearing lower limb radiographs and is performed with conventional femoral and tibial cutting guides. Questions have been raised about the accuracy ...

BMC2021

Body Dust: Well Beyond Wearable and Implantable Sensors

Sandro Carrara

Over the last 20 years, the field of Smart Dust has been proposed and demonstrated. Almost in the same period, implantable and wearable sensors for human monitoring have been actually successfully introduced in the market. The present research about Smart ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Lakshmi Devi Chakkarapani

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

2020

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Atomistic simulation and electron microscopy to characterize grain boundaries in doped beta-tricalcium phosphate ceramics

Gabrielle Anne Laguisma Sblendorio

EPFL2021

Advantages of patient-specific cutting guides with disposable instrumentation in total knee arthroplasty: a case control study

Brigitte Jolles-Haeberli

BMC2021

Body Dust: Well Beyond Wearable and Implantable Sensors

Sandro Carrara

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Lakshmi Devi Chakkarapani

2020