Facile lipid nanoparticle size engineering approach via controllable fusion induced by depletion forces

Lipid nanoparticles (LNPs) are among the most promising drug delivery carriers in research and development, with one major clinical application being messenger RNA (mRNA) vaccine. Current LNP production methods have the limit of generating low polydispersity index (PDI; PDI < 0.1) only for relatively small particles (