A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity

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Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Silvestro Micera, Simone Romeni, Bianca Ziliotto

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

IEEE2023

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Luca Pierantoni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study

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Vagus nerve stimulation (VNS) is an FDA-approved technique for the neuromodulation of the autonomic nervous system. There are many therapeutic applications where VNS could be used as a therapy, such as cardiovascular diseases, epilepsy, depression, and inf ...

IEEE2023

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

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The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

EPFL2023

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Hilal Lashuel, Yogesh Singh Chauhan, Florian Lang, Joan Romani Aumedes, Yogesh Singh

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

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CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

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The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) become activated during bacteri ...

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Novel Design and Implementation of a Neuromuscular Controller on a Hip Exoskeleton for Partial Gait Assistance

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Exoskeletons intended for partial assistance of walking should be able to follow the gait pattern of their users, via online adaptive control strategies rather than imposing predefined kinetic or kinematic profiles. NeuroMuscular Controllers (NMCs) are ada ...

2023

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

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Animal locomotion is the result of complex and multi-layered interactions between the nervous system, the musculo-skeletal system and the environment. Decoding the underlying mechanisms requires an integrative approach. Comparative experimental biology has ...

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Cancer hallmarks intersect with neuroscience in the tumor microenvironment

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The mechanisms underlying the multistep process of tumorigenesis can be distilled into a logical framework involving the acquisition of functional capabilities, the so-called hallmarks of cancer, which are collectively envisaged to be necessary for maligna ...

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Mechanisms underlying reinforcement learning of motor skills

Pierre Theopistos Vassiliadis

Motor learning allows animals, including human beings, to acquire skills that are es-sential for efficient interactions with the environment. This ability to learn new motor skills is of great practical relevance for daily-life activities (such as when lea ...

EPFL2023

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