TUCUXI: TUCUXI: An Intelligent System for Personalized Medicine from Individualization of Treatments to Research Databases and Back

Publications associées (29)

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The Digital Ethics Canvas: A Guide For Ethical Risk Assessment And Mitigation In The Digital Domain

Patrick Jermann, Cécile Hardebolle, Vladimir Macko, Adrian Christian Holzer, Vivek Ramachandran

Ethical concerns in the digital domain are growing with the extremely fast evolution of technology and the increasing scale at which software is deployed, potentially affecting our societies globally. It is crucial that engineers evaluate more systematical ...

2023

Determination of a clinically effective evobrutinib dose: Exposure-response analyses of a phase II relapsing multiple sclerosis study

Mitchell David Anderson

The pharmacometric analysis of the double-blind, randomized, phase II study (NCT02975349) investigating the safety and efficacy of evobrutinib, explored exposure-response relationships and suitable dosing regimens of evobrutinib for relapsing multiple scle ...

WILEY2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

David Lyndon Emsley, Pierrick Berruyer, Andrea Bertarello

The determination of intracellular drug concentrations can provide a better understanding of the drug function and efficacy. Ideally, this should be performed nondestructively, with no modification of either the drug or the target, and with the capability ...

AMER CHEMICAL SOC2022

A Comprehensive Timing Model for Accurate Frequency Tuning in Dataflow Circuits

Paolo Ienne, Andrea Guerrieri, Lana Josipovic, Carmine Rizzi

The ability of dataflow circuits to implement dynamic scheduling promises to overcome the conservatism of static scheduling techniques that high-level synthesis tools typically rely on. Yet, the same distributed control mechanism that allows dataflow circu ...

IEEE COMPUTER SOC2022

Steps parameters of elderly patients hospitalised for an acute medical illness in a Swiss University Hospital: an observational pilot study

Anisoara Ionescu, Francesco Tommasini

BACKGROUND: Objective mobility goals for elderly hospitalised medical patients remain debated. We therefore studied steps parameters of elderly patients hospitalised for an acute illness, to determine goals for future interventional trials and medical prac ...

SMW supporting association2022

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Christoph Merten, Ngoc Hien Du

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

Nature Research2022

A Game-Based Approach to Develop Engineering Students’ Awareness About Artificial Intelligence Ethical Challenges

Patrick Jermann, Roland John Tormey, Cécile Hardebolle, Helena Kovacs, Jessica Elke Dehler Zufferey, Maria Carla Di Vincenzo, Ester Simkova

The past few decades have seen important efforts to introduce more ethics into engineering education programs around the world, while adapting to the evolution of ethical concerns, notably in relation to digital technology and artificial intelligence. Even ...

2022

Emotional empathy and engineering students’moral reasoning

Roland John Tormey, Nihat Kotluk

Although engineering education is often characterized as a rational activity, research suggests that emotions are vital for learning at all levels of education. In ethics education, there is evidence that including mild emotional information in case studie ...

2022

Data integration for the numerical simulation of cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani

The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...

WILEY2021

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