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This lecture introduces the scientific approach, emphasizing the importance of experimentation and critical thinking in testing hypotheses. It explores the history of radioactivity discovery, focusing on Henri Becquerel's experiments. The lecture also covers key concepts in the scientific process, such as hypothesis testing and peer review. Additionally, it delves into metrology, explaining the measurement process, error analysis, and calibration techniques. Various types of errors in measurements, including systematic and random errors, are discussed, along with methods to minimize them. The importance of accuracy, precision, and fidelity in measurements is highlighted, along with the impact of calibration errors. Overall, the lecture provides a comprehensive overview of the scientific method and the fundamental principles of metrology.