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This lecture delves into the key concepts of Implementation Research (IR), focusing on the identification and investigation of problems hindering the effective implementation of health interventions. Dr. Hans Remme from the World Health Organization explains the three key phases in IR: defining the implementation problem, designing implementation strategies, and testing these strategies in real-life settings. The lecture also covers related research areas such as operational research, intervention research, and effectiveness research. Key characteristics of IR, including complexity, focus on innovation, and challenges such as the need for recognition and separating research from implementation, are discussed. The importance of IR in developing effective strategies for infectious diseases of poverty is emphasized.