Hsp70 Interaction with Measles Virus Nucleoprotein

This lecture explores the interaction between hsp70 and the intrinsically disordered Ntail domain of the measles virus nucleoprotein. It delves into the pivotal role of the P protein in transcription and replication, the characteristics of intrinsically disordered proteins, and the a-helical folding of the MeV NTAIL upon binding to the X domain of P. The lecture also covers the molecular partnership of NTAIL, the impact of hsp70 on viral proteins, and the modulation of hsp70-substrate interactions. Furthermore, it discusses the split-GFP re-assembly assay principle, the rational design of mutated MORE variants, and the implications of phase transition and fibril formation in viral proteins.