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This lecture covers the pharmacology of pain, focusing on the four steps in pain sensation: transduction, conduction, transmission/modulation, and perception. It discusses the mechanisms of transduction, sensitizing agents, central and peripheral sensitization, opioid receptor agonists, actions of NSAIDs, and migraine therapy. The instructor explains the different downstream signaling pathways of u opioid receptor agonists and approaches for treating neuropathic pain.