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This lecture covers the importance of differential measurement in reducing interference, the role of shielding and grounding in protecting signals, the concept of guarding the input to prevent leakage currents, the use of shielded cables and pairs to reduce RF coupling, methods for breaking ground loops, and the significance of decoupling power supply to minimize AC impedance. Examples for shielding bioelectrodes are also discussed, emphasizing the need for extensive shielding. The instructor highlights the fundamental nature of noise in resistive systems, the impact of interference from preamplifiers, and ways to mitigate noise through proper amplification, bandwidth reduction, and interference reduction techniques.