This lecture covers the concept of the water window in electrochemistry, discussing the potential range where electrode materials remain stable. It delves into charge injection capacity, limits, and safety considerations for neural stimulation, emphasizing the importance of electrode materials, coatings, and structures. The influence of mechanics on tissue damage is explored, along with the role of insulating materials and encapsulation in bioelectronic devices. The presentation also touches on optimal electrode characteristics for efficient and safe stimulation, highlighting low energy consumption, high charge injection limits, and long-term stability in the body.