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This lecture covers the fabrication challenges and novel properties of nanoscale semiconductors, focusing on nanowires and related heterostructures. Topics include epitaxy, nanowires as building blocks for solar cells, applications in quantum computing, and the engineering of light absorption. The lecture also discusses the epitaxial systems, growth modes, homo and heteroepitaxy, and the challenges and opportunities of III-V nanowires. Furthermore, it explores the selective area epitaxy of nanoscale membranes, transport properties, and the potential of nanowires in dual-junction solar cells. The lecture concludes with insights into materials challenges, device structures, and the future prospects of nanoscale semiconductors.