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This lecture covers the concept of a thermodynamic system and the first principle, focusing on an isolated system with a mass attached to a spring oscillating in a viscous fluid. It discusses state variables, energy functions, internal energy, and the evolution of the system over time. The lecture also explores the forces acting on the system, including external forces and the center of mass theorem. Additionally, it delves into deformable systems, closed systems, and the relationship between energy and temperature. Practical experiments like Franklin's boiling experiment are used to illustrate key principles.