This lecture explores non-invasive deep brain stimulation techniques such as deep TMS and tTIS, focusing on altering deep brain regions in neuro-psychiatric disorders, neuromodulation effects, and challenges in focal stimulation. It delves into the CE-marked applications of deep TMS for various disorders and the potential of tTIS for temporal interference stimulation. The presentation covers the electric field distribution, coil types, and effectiveness, emphasizing the need for focal and non-invasive approaches. Additionally, it discusses the applications of tTIS in humans, including its effects on high-frequency neural operation and spatial memory. The lecture concludes with insights into the equipment used for tTIS and the future prospects and challenges in personalized neuromodulation.