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This lecture covers the design and manufacturing of flexible devices, focusing on shape morphing technologies like foldable displays and materials used in OLED and TFT interconnects. It also delves into the development of high-density brain electrodes for neural interfaces, discussing micron-scale threads and electrode designs. The challenges of selecting materials and manufacturing methods, as well as the properties of flexible substrates like glass, metal foils, and polymer substrates, are explored. The use of thermoplastics and polymeric plastic substrates such as PET and PEN in flexible electronics is also discussed, along with polyimide films for their thermal and mechanical stability.