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This lecture covers the pharmacology of the autonomic nervous system, including the effects of atropine, botulinum toxin, acetylcholine, and catecholamines. It explains the role of various activators and provides examples of poisoning and therapeutic uses of muscarinic agonists. The lecture also discusses the cholinergic and adrenergic synapse, different types of cholinomimetics, desensitization of adrenergic receptors, and the clinical uses of sympathomimetics and sympatholytics. Additionally, it delves into the mechanism of action of motor plaque cholinesterase inhibitors and the classification of cholinergic and adrenergic receptors. The effects of norepinephrine and adrenaline on the heart and smooth muscle cells are also explored.