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This lecture covers the fundamentals of machine learning, including the definition of machine learning, the difference between human and machine learning, supervised classification, labeled training sets, generic schemes, and applications in medical research, spam detection, and recommender systems. It also delves into topics such as nearest-neighbor classifiers, decision boundaries, training versus testing, polynomial curve fitting, underfitting, overfitting, and the importance of choosing the right k value in k-nearest-neighbor classifiers.