Cortex-Wide Opto-Electrophysiological Recordings: eSee-Shells

This lecture discusses the development of 'eSee-Shells', chronic multimodal neural interface devices using transparent, inkjet-printed electrocorticography (ECoG) arrays. The speaker, Prof. Sarah Swisher, presents the benefits of flexible electronics for sensing neural activity across multiple brain regions. The talk covers the fabrication process of transparent electrode arrays, the simultaneous recording of ECoG and calcium imaging in awake mice, and the advantages of large-area implants for studying individual neurons and cortical networks. The lecture also explores the unique properties of the PEDOT:PSS interface, the impedance of electrode arrays, and the chronic durability of implanted eSee-Shells for over 100 days.