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This lecture provides an overview of genetic transmission, focusing on the probability of disease inheritance. The instructor discusses the calculation of risks for genetic diseases, such as Duchenne muscular dystrophy, using examples of X-linked recessive disorders. The lecture covers the application of Bayes' theorem to determine the likelihood of disease transmission in families. Through detailed explanations and genetic scenarios, the instructor guides students in understanding the complex interplay between genetic inheritance and disease manifestation. The lecture also delves into the use of genetic testing and probability calculations in real-life scenarios, such as paternity testing and selective breeding in agriculture.