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This lecture covers the principles of glomerular filtration and renal function, focusing on scenarios involving anemia, aging, and PAH clearance. It discusses the impact of changes in cardiac output on renal blood flow, the calculation of glomerular filtration rate, and the consequences of altered renal function in elderly patients. Additionally, it explores the clearance of PAH and its implications for renal function assessment. The lecture concludes with a detailed analysis of sodium filtration, water reabsorption, and the regulation of extracellular volume in response to changes in sodium levels.