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This lecture covers the analysis of acidity in organic molecules, focusing on the removal of protons and the factors affecting acidity such as electronegativity, hybridization, and resonance stabilization. It also discusses the importance of resonance structures in stabilizing bases and justifying acidity trends. The session includes exercises on identifying acidic bonds, determining hybridization, and drawing orbital interactions to explain acidity variations. Additionally, it explores exceptions to acidity trends, inductive effects, and the impact of atom size on basicity. The lecture concludes with a detailed examination of resonance stabilization and its role in determining the strength of acids and bases.