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This lecture explores the shift from reductionism to holism in biology, focusing on the integrative ideal and the return of complexity thinking. It delves into the concept of 4Ps Medicine, a promise to capture the complexity of the human body and disease through a holistic approach. The history of biomedicine, the evolution of data regimes in healthcare, and the challenges of embracing complexity in health and disease are discussed. The lecture also addresses the role of technologies in sustaining the ethical and political legitimacy of integrative medicine, emphasizing the need for an integrative model that encompasses various levels of data and knowledge production.