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This lecture covers the motor system, motor neuron diseases, and amyotrophic lateral sclerosis. It explains the control of voluntary movements, movement execution, and the role of the basal ganglia in the motor system. The lecture also delves into the organization of the motor system, upper and lower motor neurons, and the descending tracts in the spinal cord. Additionally, it discusses the motor cortex, spinal cord organization across mammalian species, and the neuromuscular system. The presentation concludes with insights into the spinal cord circuit for movement control, motor units, and the neuromuscular junction.