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This lecture by the instructor covers the topology and mechanical properties of the nervous system, exploring its multi-scale organization from the organ level to the cellular level. It delves into the functions of glial cells, brain sizes across species, brain stiffness, micromotion, brain folding, and cortex curvature. The presentation also discusses key concepts in mechanics such as tension, compression, and folding instability, along with methods for measuring brain mechanical properties like indentation. Various images and diagrams are used to illustrate the concepts discussed.