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This lecture explores the epidemiology, transmission, and prevention strategies of Chagas disease, a neglected illness caused by the parasite Trypanosoma cruzi. The instructor discusses the acute and chronic phases of the disease, its symptoms, modes of transmission, and the challenges faced in controlling its spread, focusing on a study conducted in the south of Ecuador between 2005 and 2009. The study revealed high infestation rates of the vector insect, highlighting the limitations of insecticide fumigation as a sustainable solution. The lecture emphasizes the importance of prevention measures, such as community-wide insect control campaigns and serological screenings, to reduce the disease's impact in endemic regions.