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This lecture covers the definition and motivations for developing neural interfaces, including those with the central and peripheral nervous systems. It discusses the design principles of invasive bidirectional neural interfaces, emphasizing the importance of safety, efficacy, and integration with neuroprostheses. The evolution of cortical interfaces from first to third generation is explored, highlighting advancements in electrode technology and materials. The lecture also delves into the challenges and innovations in regenerative and intraneural electrodes, as well as the potential of nanotechnology in creating interfaces at the subcellular level.