G Protein-Coupled Receptors: Signalling Diversity

This lecture delves into the intricate world of G protein-coupled receptors (GPCRs), focusing on their structure, activation, and signalling pathways. The slides cover topics such as the prominent class of 7TM receptors, ligand-induced bias effects, and the diverse responses triggered by different ligands. The lecture explores the activation of G proteins, the role of arrestin-mediated signals, and the implications of ligand bias on signalling pathways. It also discusses the internalisation of GPCRs and the functional oligomers formed by receptors. The presentation concludes with insights into the cellular localisation of GPCRs, including their activity within the cell and the potential signalling from endosomes.