This lecture covers an overview of the nervous system, neuron modelling, signal transmission, the Vagus nerve, epilepsy, Vagus nerve stimulation, insomnia, and transcutaneous VNS. It explores the autonomic effects on various organs, action potential propagation, and the limitations and specifications of VNS devices. Clinical studies on epilepsy and depression, as well as the impact of VNS therapy on patients, are discussed. The lecture also delves into the Vagus nerve, its functions, and the implications of its stimulation. The use of transcutaneous VNS devices, their limitations, and the potential benefits are highlighted, along with the parasympathetic and sympathetic systems' effects on different organs.