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This lecture explores self-organization in natural systems, where global patterns emerge from local interactions. It delves into foraging strategies of ants, including individual navigation, recruitment mechanisms, and the formation of recruitment trails. The role of randomness in foraging organization and the biological significance of exploitation-exploration balance are discussed. The lecture also covers the Traveling Salesman Problem and Ant Colony Optimization algorithms, showcasing how artificial systems can mimic natural behaviors to solve complex problems.