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This lecture covers the principles and applications of Tissue Optics, focusing on Optical Coherence Tomography (OCT) and the use of light scattering in photomedicine. It explains the metrics for optical scattering, tissue optical parameters, and the sources of scattering in tissues. The lecture also delves into the medical applications of OCT in ophthalmology, dermatology, cardiology, and gastroenterology, highlighting its role in non-invasive diagnostics and guided surgery. Additionally, it discusses the advantages of Frequency Domain OCT (FD-OCT) over Time Domain OCT, the implementation of OCT systems, and the various light sources used in OCT imaging.