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This lecture delves into John Snow's groundbreaking work in epidemiology during the 19th century, focusing on his spatial investigations of cholera outbreaks in London. By analyzing data on cholera deaths and water supplies, Snow developed a theory that challenged prevailing beliefs about the disease's transmission. The lecture explores Snow's 'Grand Experiment' and how he used spatial analysis to identify the source of the outbreaks, ultimately revolutionizing the field of epidemiology. The presentation also highlights the importance of asking the right questions in spatial analysis and prioritizing theory testing over data exploration.