Ligand-gated Ion Channels

This lecture covers the fundamental concepts of ligand-gated ion channels, including the structure and function of nicotinic acetylcholine receptors. It discusses the ligand-binding sites, ion selectivities, and the allosteric gating mechanism of these channels. The lecture also explores the importance of studying ion channels in biology, biophysics, medicine, and drug development, highlighting their role in diseases and drug targeting. Additionally, it delves into the composition, location, and disorders related to neuronal and muscle-type nicotinic acetylcholine receptors, as well as the structure and homologous proteins of Cys-loop receptors.