This lecture covers variance reduction techniques in optimization, focusing on gradient descent (GD) and stochastic gradient descent (SGD) methods. The instructor explains how to decrease variance while using a constant step-size, introducing concepts like Lipschitz smoothness and the observation of GD vs. SGD steps. The lecture also delves into the mathematics of data, from theory to computation, with a special emphasis on deep learning. Various algorithms and methods, such as SVRG and mini-batch SGD, are discussed to reduce the variance of stochastic gradients. The lecture explores the challenges in deep learning theory and applications, including fairness, robustness, interpretability, and energy efficiency.