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This lecture delves into the concept of architecture as the act of separating interior and exterior, earth and sky, transforming nature into culture. It explores the significance of tracing a perimeter as the first architectural and anthropological sign, creating a controlled microcosm and an infinite external macrocosm. The discussion emphasizes the transformation of natural conditions into cultural ones, challenging the perception of unchanging landscapes. The lecture also touches upon the idea that understanding the territory's accidents and mutations allows for smarter interventions, highlighting the importance of careful consideration in planning. Through quotes from Mario Botta and André Corboz, the lecture invites reflection on the evolving relationship between human settlements and the environment, shedding light on the dynamic nature of architectural spaces.